In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his brother and himself... the legendary Philosopher's Stone.

There are many types of alchemy in the world. Edward's commanding officer, "Flame Alchemist" Roy Mustang, can control fire. Shou Tucker, the "Sewing-Life Alchemist," specializes in the most difficult alchemy of all...biological transmutation, the ability to alter the tissue of living things. But no matter what their power, alchemists are still human. And when a mysterious killer begins stalking state alchemists, no one can escape his vengeance...