A murderer is stalking and scalping white men in Seattle. While this so-called Indian Killer terrorizes the city, its Native American population is thrown into turmoil. John Smith, an Indian adopted as a newborn baby into a white family, is increasingly dissatisfied with his life and dreams of the existence he might have led on the reservation - he is gently descending into madness.

In his search for connection he meets Marie, a strident young student at the local university who is isolated from her tribe; she is highly educated, but not in her own traditions. Marie is particularly enraged with people such as Jack Wilson, a local ex-cop and now a popular mystery writer who passes himself off as part Indian in a desperate attempt at acceptance.

. Jack is determined to write about the brutal killings in his next novel, a novel that he believes will truly reveal what it is like to be Indian. With each new murder, the city is gripped by fear, and hate crimes perpetrated by white men against the Native American community grow increasingly violent. As the murderer searches for his latest victim, and the Indian population of Seattle is filled with a strange combination of fear and relief, Indian Killer builds to an unexpected and terrifying climax.