Readers in the sixteenth century read (that is, interpreted) texts quite differently from the way contemporary readers do; they were trained to notice different aspects of a text and to process them differently.

Using educational works of Erasmus, Ascham, and others, commentaries on literary works, various kinds of religious guides and homilies, and self-improvement books, Kintgen has found specific evidence of these differences and makes imaginative use of it to draw fascinating and convincing conclusions about the art and practice of reading. Kintgen ends by situating the book within literary theory, cognitive science, and literacy studies.

Among the writers covered are Gabriel Harvey, E. K. (the commentator on The Shepheardes Calendar), Sir John Harrington, George Gascoigne, George Puttenham, Thomas Blundeville, and Angel Day.