This volume contains the proceedings of the workshop on Variation and Optimal Control Problems on Unbounded Domains, held in memory of Arie Leizarowitz, from January 9-12, 2012, in Haifa, Israel. The workshop brought together a select group of worldwide experts in optimal control theory and the calculus of variations, working on problems on unbounded domains. The papers in this volume cover many different areas of optimal control and its applications. Topics include needle variations in infinite-horizon optimal control, Lyapunov stability with some extensions, small noise large time asymptotics for the normalized Feynman-Kac semigroup, linear-quadratic optimal control problems with state delays, time-optimal control of wafer stage positioning, second order optimality conditions in optimal control, state and time transformations of infinite horizon problems, turnpike properties of dynamic zero-sum games, and an infinite-horizon variational problem on an infinite strip.