When Deborah Knott's terminally ill aunt, Rachel, is found smothered to death in her bed at a hospice center, all of her Colleton County kith and kin are shocked. Who kills a dying woman? As Deborah and her husband, Sheriff's Deputy Dwight Bryant, try to find Rachel's killer, they cross paths with the Designated Daughters, a support group for caregivers, not all of whom are women. Rachel's flamboyant daughter, Sally, is a member, and when a con artist cheats one of the group, they swing into action. They want more than just a shoulder to cry on-they want revenge.