Hetty "Handful" Grimké, an urban slave in early nineteenth century Charleston, yearns for life beyond the suffocating walls that enclose her within the wealthy Grimké household. The Grimké's daughter, Sarah, has known from an early age she is meant to do something large in the world, but she is hemmed in by the limits imposed on women. On Sarah's eleventh birthday, she is given ownership of ten year old Handful, who is to be her handmaid. Over the next thirty-five years, both women strive for a life of their own, dramatically shaping each other's destinies and forming a complex relationship marked by guilt, defiance, estrangement and the uneasy ways of love. As the stories build to a riveting climax, Handful will endure loss and sorrow, finding courage and a sense of self in the process. Sarah will experience crushed hopes, betrayal, unrequited love, and ostracism before leaving Charleston to find her place alongside her fearless younger sister, Angelina, as one of the early pioneers in the abolition and women's rights movements.

This story follows Hetty, a young slave, and Sarah, from a wealthy family, starting on Sarah's 11th birthday, when she is given ownership of Hetty, through the next 35 years of their lives. The plot contains sexual situations and graphic violence.